{"id":6765,"date":"2026-10-02T15:00:06","date_gmt":"2026-10-02T08:00:06","guid":{"rendered":"https:\/\/pskclinicbkk.com\/department\/tadalafil\/"},"modified":"2026-10-12T12:39:00","modified_gmt":"2026-10-12T05:39:00","slug":"tadalafil","status":"publish","type":"service","link":"https:\/\/pskclinicbkk.com\/en\/department\/tadalafil\/","title":{"rendered":"What Is Tadalafil? Dosage, How to Use, and Side Effects You Should Know"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

People looking for information on erectile dysfunction medication often come across the name Tadalafil, yet many are unsure how it works, whether it is safe, and how it differs from other drugs. This article gathers the key information in an easy-to-understand form \u2014 from how it works, dosage, and side effects to precautions \u2014 so you can consult a doctor with confidence.<\/span><\/p>\n

Sexual performance is a health topic that can be discussed normally; it is nothing to be ashamed of. Quite a few men face this problem at some point in life, and having accurate knowledge is a good starting point for taking care of yourself.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\u0e22\u0e32\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

What is Tadalafil and What Does It Treat?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Tadalafil is a medication in the phosphodiesterase type 5 inhibitor (PDE 5 inhibitor) class. It is used mainly to treat erectile dysfunction (ED), and it is also used to treat benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension.<\/p>\n

This medication is known under the brand name Cialis for the ED and enlarged-prostate indications, while for pulmonary arterial hypertension it is sold under the brand name Adcirca. Tadalafil was developed by Eli Lilly.<\/p>\n

Tadalafil has three main approved indications: treating erectile dysfunction in men, relieving the symptoms of an enlarged prostate such as difficulty urinating or frequent urination, and treating pulmonary arterial hypertension that causes easy fatigue. The doctor will choose the indication and dose that suit each individual’s symptoms.<\/p>\n

The U.S. Food and Drug Administration (FDA) has approved Tadalafil for treating ED since 2003. In Thailand, the medication is registered with the Food and Drug Administration (Thai FDA) for example, Cialis film-coated tablets at 5 mg, registration number 1C 28\/63(N).<\/p>\n

Tadalafil is a classified as a “specially controlled medication” under the announcements of the Thai FDA. It must be prescribed by a doctor and its sales are reported to the FDA, so it cannot be bought over the counter at a general pharmacy. It should note be purchased from unlicensed online sources, because of the risk of counterfeit or substandard medication.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t

What Is Erectile Dysfunction (ED) and What Causes It?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Erectile dysfunction (ED) is a condition in which the penis does not become firm enough, or does not stay firm long enough, for sexual intercourse on a consistent basis. This condition is common and is often linked to overall vascular health, so it is not merely a sexual problem.<\/span><\/p>\n

The Massachusetts Male Aging Study found that about 52% of men aged 40\u201370 had some degree of ED, with the risk rising with age. This figure reflects that ED is a normal, treatable condition \u2014 not something you have to keep to yourself.<\/span><\/p>\n

The causes of ED fall into two main groups. The first is physical causes, such as diabetes, high blood pressure, high blood lipids, cardiovascular disease, low male hormone levels, and the effects of smoking. The second is psychological causes, such as stress, anxiety, depression, and relationship problems.<\/span><\/p>\n

Common risk factors include increasing age, smoking, excessive alcohol consumption, being overweight, and a lack of exercise. People with diabetes have about four times the risk of developing ED compared with the general population, and often have more severe symptoms. Understanding the cause helps the doctor plan treatment precisely, rather than simply prescribing medication<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t

How Does Tadalafil Work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Tadalafil works by inhibiting the PDE5 enzyme, allowing the blood vessels around the penis to dilate better and for longer, so blood flows in sufficiently for an erection. However, the medication only takes effect when there is also sexual stimulation.<\/p>\n

When sexual stimulation occurs, the body releases nitric oxide, which relaxes the blood vessels. This substance triggers the production of cGMP, which dilates the blood vessels, The PDE5 enzyme is responsible for breaking down cGMP; when the medication inhibits this enzyme, cGMP last longer, so the blood vessels stay dilated long enough for and erection.<\/p>\n

A common misconception is that this medication creates sexual arousal on its own, but in reality it does not. If the user has no sexual stimulation, the medication will not produce an erection. The drug is therefore an aid that supports the body’s own function, not a creator of arousal.<\/span><\/p>\n

Tadalafil is metabolized in the liver mainly through the CYP3A4 enzyme. This point is important because certain drugs or foods that interfere with this enzyme can change the drug’s level in the blood as explained in the section on drugs that must not be together.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t

How Is Tadalafil Different for Sildenafil (Viagra)?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

The main difference is the duration of action: Tadalafil stays active in the body for up to 36 hours, while Sildenafil lasts about 6\u20138 hours. In addition, food does not affect the absorption of Tadalafil, so Tadalafil can be taken with meals \u2014 unlike Sildenafil, which should be taken on an empty stomach because taking Sildenafil with food reduces its absorption.<\/span><\/p>\n

Tadalafil has a half-life of about 17.5 hours, much longer than other drugs in the same class, which is why it has the nickname “the weekend pill” \u2014 a single dose covers a long window, helping couples avoid worrying about timing and making their time together feel more natural.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u00a0<\/p>\n\n

\n\n\n\n\n\n\n\n\n\n\n\n
Item<\/th>\nTadalafil\u00a0<\/th>\nSildenafil\u00a0<\/th>\n<\/tr>\n<\/thead>\n
Brand name<\/th>\nCialis<\/td>\nViagra<\/td>\n<\/tr>\n
Duration of action<\/th>\nUp to 36 hours<\/td>\n6-8 hours<\/td>\n<\/tr>\n
Onset of action<\/th>\n~30-45 minutes<\/td>\n~30-60 minutes<\/td>\n<\/tr>\n
effect of food on absorption<\/th>\nFood has no effect on absorption<\/td>\nFood reduces absporption<\/td>\n<\/tr>\n
Daily use<\/th>\nStarts at 2.5-5 mg\/day<\/td>\nNot common<\/td>\n<\/tr>\n
On-demand use<\/th>\nStarts at 10 mg<\/td>\nStarts at 25 mg<\/td>\n<\/tr>\n
Maximum does within 24 hrs<\/th>\nNo more that 20 mg<\/td>\nNo more that 100 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n